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Non-small cell lung cancer transdifferentiation into small cell lung cancer: A case series
(2018)
Transdifferentiation from non-small cell lung cancer (NSCLC) to small cell lung cancer (SCLC) has been reported mostly in adenocarcinomas and has been described as a cause of acquired tyrosine kinase inhibitor (TKI) ...
Evolutionary origin of endochondral ossification: the transdifferentiation hypothesis
(2017)
The vertebrate endoskeleton results from the piecemeal assembly of bone and cartilage as well as additional types of calcified extracellular matrices produced by seemingly hybrid cell types of intermediate phenotypes between ...
Mesenchymal stem cell therapy for equine tendinitis
(2013-03-28)
Tendinitis is an important disease that leads to lameness and decreased performance in equine athletes and results in high costs associated with therapy due to a long recovery period and a high rate of recurrence. Although, ...
Cellular and molecular effects of Baccharis dracunculifolia D.C. and Plectranthus barbatus Andrews medicinal plant extracts on retinoid metabolism in the human hepatic stellate cell LX-2
(2019-08-22)
Background: Chronic hepatic diseases are serious problems worldwide, which may lead to the development of fibrosis and eventually cirrhosis. Despite the significant number of people affected by hepatic fibrosis, no effective ...
Netrin-1 in glioblastoma neovascularization: the new partner in crime?
(MDPI, 2021)
Glioblastoma (GBM) is the most aggressive and common primary tumor of the central nervous system. It is characterized by having an infiltrating growth and by the presence of an excessive and aberrant vasculature. Some of ...
Ontogeny of fusoid cells in Guadua species (Poaceae, Bambusoideae, Bambuseae): evidence for transdifferentiation and possible functions
(Elsevier Gmbh, 2016-06)
Fusoid cells have been interpreted as cells or intercellular spaces, according to different authors. Here, structural and ultrastructural evidence is provided relative to the origin and changes experimented by chlorenchyma ...
JNK mediates TGF-beta 1-induced epithelial mesenchymal transdifferentiation of mouse transformed keratinocytes
(ELSEVIER, 2006-10-02)
In this study we analyzed the role of the c-Jun N-terminal kinases (JNK) pathway in the TGF-beta 1 stimulation of urokinase-type plasminogen activator (uPA), initial stages of epithelial-mesenchymal transdifferentiation ...